Test 8 drugs Oratect Plus (2024)

Device for drug screening
and alcohol in the oral fluid
ME / TH / CO / AM / OP / PC or BZ and alcohol

Intended use

CE Medical Device.
OratectPlus for the screening of drugs and alcohol in the oral fluid is an in vitro diagnostic device exclusively for use by medical personnel. OratectPlus for oral drug and alcohol screening is intended for use in the simultaneous detection of various drugs or related metabolites and alcohol in the human oral fluid. The device provides qualitative results for cocaine, methamphetamine, MDMA (ecstasy), THC (cannabinoids), amphetamine, opiates, phencyclidine, benzodiazepines and alcohol in human oral fluid at the following cutoff concentrations:

MYSELF d-Methamphetamine / MDMA 25 ng / ml
TH Δ9-Tetrahydrocannabinol 40 ng / ml
CO Cocaine 20 ng / ml
AM d-Amphetamine 25 ng / ml
OP Morphine 10 ng / ml
PC phencyclidine 4 ng / ml
BZ Diazepam 5 ng / ml
TO THE Alcohol ≥ 0.02% BAC

The test must be performed by adequately trained personnel. It must not be used without supervision.

OratectPlus for drug and alcohol screening in the oral fluid provides only preliminary results for the alcohol / drug test. For qualitative results or for the confirmation of presumptive positive results obtained with the use of OratecPlus for loscreening of drugs and alcohol in the oral fluid, it is necessary to use a more specific alternative method.

Summary
The use of drugs and / or the consumption of excessive amounts of alcohol contribute to the occurrence of many accidents with consequent injuries and permanent porters. Individual screening for drug abuse and alcohol detection is an important method for identifying individuals who could potentially harm themselves and others.

Studies on methamphetamine, MDMA, cocaine, opiates, amphetamine, phencyclidine, benzodiazepine, cannabinoids and alcohol show that all these substances are detectable in oral fluid. OratectPlus for the screening of drugs and alcohol in the oral fluid integrates the collection of oral fluid and the simultaneous identification of drugs of abuse and alcohol in a single device.

Test principle
OratectPlus for oral drug and alcohol screening is based on:

(1) Drug test: a competitive lateral-flow enzyme immunoassay in which derivatives of immobilized membrane drugs compete with the drug (or drugs) that could be present in the oral fluid for a limited number of binding sites on the antibody-colloidal gold conjugate colored. During the test the oral fluid is deposited on the collection pad and from there migrates through the membrane. If no drugs are present in the fluid, the colored colloidal antibody-gold conjugate binds aiderivatives present on the membrane to form visible bands in specific areas of the test. Therefore, the presence of a colored band in a specific area of the test indicates a negative result . In the event that any of the drugs indicated above is present in the oral fluid, it competes with the immobilized conjugate for the limited number of binding sites of the colloidal conjugate with colored gold. A sufficient amount of drug is present in the sample, the antibodies break down and the colloidal conjugate with gold cannot bind to the derivatives of the membrane drug. Therefore, the absence of a colored band in the test area indicates a presumptive positive result for that particular drug .

Fig. A Description of the test areas of the OratectPlus device for the screening of oral and alcohol fluids.

The presence of a blue line in each window indicates that the device has not yet been used. Exceeding the blue line indicates that a sufficient amount of oral fluid has been collected.

A control band in the appropriate area (C) indicates that the test has been performed correctly. This control band must always appear, independent of the presence of drugs or their metabolites.

(2) Alcohol test: in contact with the alcohol present in the oral fluid, a buffer covered with enzymes changes color gradually passing through the variety of green and blue. The alcohol test buffer uses a solid phase agent that uses the following highly specific enzymatic reaction:

Alcohol oxidase
CH 3 CH 2 OH + O 2 --------------> CH 3 C = O + H 2 O 2
peroxidase
H 2 O 2 + DH 2 --------------> D Blue + 2H 2 O

During the test, the oral fluid is collected on the pad and saturated. If alcohol is not present in the fluid, the buffer remains colorless (it remains white or colorcrema) because no reaction takes place with enzymes that can cause discoloration. When alcohol is present in the oral fluid, the sicolora buffer of a shade between green and blue because alcohol reacts by producing aldehyde and peroxide. Hydrogen liberated through the peroxidase reaction which leads to the formation of the blue color. Therefore, the presence of a green-blue color on the pad indicates a presumed positive result for the alcohol test.

Reagents
OratectPlus for drug and alcohol screening in the oral fluid contains:

(1) Test for drugs: the drug test consists of two membrane strips and a collection pad. Each strip consists of a membrane, a colloidal gold conjugate pad, a swab for the sample and a swab absorbent.

Membrane : test strip for ME / TH / CO In a specific area of the membrane, referred to as the "Test Zone", dimethanfetamine, THC and cocaine protein conjugates were absorbed.

Test strip for AM / OP / PC or AM / OP / BZ: amphetamine, morphine, and phencyclidine, amphetamine, morphine and benzodiazepine conjugates have been absorbed into the membrane test area.

Conjugate gold buffer with colloidal gold : the buffer strip of the colloidal conate conjugate for the ME / TH / CO test contains conjugates with colloidal gold of methamphetamine antibodies, anti THC and anti cocaine absorbed on a fiber pad. The colloidal conjugate with colloidal gold for the AM / OP / PC or AM / OP / BZ test contains colloidal conoroidal conjugates of anti-amphetamine antibodies, anti morphine and anti phencyclidine or anti-amphetamine antibodies, anti morphine and anti benzodiazepine.

(2) Alcohol test - The alcohol pad contains
Tetramethylbenzidine Alcohol oxidase
peroxidase
Buffer e
Stabilizing proteins

Material supplied

OratectPlus for drug and alcohol screening in the oral fluid contains:
1. 1 insert
2. 1 guide
3. 25 test devices: each device consists of a plastic support and a removable cap. The devices are individually packaged in an aluminum bag with desiccant and oxygen absorbent material.
4. 1 plastic vial containing the confirmatory test swab

Materials requested but not supplied
• Time measurement device

Warnings and precautions
• OratecPlus for drug and alcohol screening in the oral fluid is indicated exclusively for in vitro diagnostic use.
• The test device must remain in the original packaging until it is used.
• If the package is torn or cut the device must be discarded.
• Do not use the device beyond the expiry date stated on the package.
• Treat all saliva samples as potentially infected. Proper procedures for the treatment and disposal of the product must be established.
• The results should not be interpreted by color-blind or disturbing people.

The alcohol test has been studied and calibrated to be interpreted 5 minutes after the start of the saliva collection procedure. If you wait for more than ten minutes, incorrect or false results may occur. The alcohol test is sensitive to the presence of ethanol. Sometimes the alcohol vapors in the air are detected by the OratecPlus device. Alcohol fumes are often present in public spaces and homes. Alcohol is a component of many household products, such as disinfectants, deodorisers and liquid for glass cleaning. If the presence of alcohol vapors is suspected, it is necessary to expose yourself and perform the test in an area that is certainly free of vapors.

The alcohol test is a visual interpretation in which each color change from green to blue is considered to be a presumed positive result with an alcohol concentration of 0.02% or higher in saliva.

Product storage
The unopened package of the OratecPlus device must be stored at room temperature, 15 ° -30 ° C (59 ° F-86 ° F), which must not exceed 30 ° C (86 ° F) . If stored in compliance with these conditions the alcohol test will follow the specifications up to the expiration date. If the storage temperature exceeds 30 ° C (86 ° F), degradation of the product and its performance may occur. Do not open the package until the test is completed.

Sample collection and processing
IMPORTANT: at least 10 minutes before the test is administered, ask the subject not to eat, drink, smoke or chew chewing gum or food based products because these behaviors can lead to incorrect results due to possible contamination of the saliva with interfering substances.

Test procedure
1. Remove the device from the sealed package.
2. Carefully remove the cap by holding it on the sides and pulling gently. In this way the collection pad and a circular pad are exposed for the alcohol content between the band and the pad.
3. Check that the blue line is present in each test band.
4. Observe the alcohol pad. The swab should be light cream in color. If the color is dark or in any way discolored before taking the saliva, the device should not be used.
5. The oral fluid collection procedure must be carefully observed. Indicate the subject to hold the device from the top (above the test window).
6. When inserting the device into the mouth, keep the head horizontal .
to. Open your mouth, insert the collection pad inside and gently roll it out several times against a cheek with a circular motion (about 15-20 times). (Fig. B)
b. Keeping the head horizontal, rub the collection pad against the opposite cheek several times (about 15-20) with a circular motion. (Fig B)

Fig. B Rub the collection pad against each end several times (about 15-20).

c. Rub the collection pad on the tongue several times (about 15-20) and then under the tongue several more times (about 15-20). (Fig. C and Fig. D). Do not chew, suck, bite or bend the collection pad.

Fig. C Rub the collection pad on the tongue several times (about 15-20).

Fig. D Rub the collection pad under the tongue several times (about 15-20).

7. Put the collection pad under the tongue for about 30 seconds to collect the laser. Instruct the donor to hold the device in place with his or her hands.
8. The flow of blue lines indicates the collection of a sufficient quantity of waste. If the blue line is still present after placing the collection pad under the tongue for 30 seconds, repeat the instructions from point 5 to point 7 until the blue line disappears (the absorption of the saliva exceeds the line)

Note: The flow of saliva over the blue line must occur in the two testentro bands five minutes. If no flow changes are observed after 5 minutes within the mouth, discard the device, review steps 4 to 7 of the procedure and repeat the test using a new device.

9. Put the cap back on the device, place it on a flat surface and read the results:
(a) The alcohol test must be read 5 minutes after removal of the device from the mouth. Do not read the result after 10 minutes. (b) The drug test should be read 5 minutes after removing the device from the mouth. Do not read the result after 30 minutes.

Interpretation of test results
(1) Alcohol test results:
(A) Negative result for alcohol When the alcohol pad shows no color changes (it remains white or cream), the result must be interpreted as negative (no alcohol is present). See Fig. E for an example of a negative alcohol test result.

In Fig. E below, the oral fluid sample is negative for alcohol because no color changes have occurred in the alcohol pad.

Fig E. Example of a negative result of the alcohol test

A result in which the outer edges of the alcohol pad stains weakly the majority of the pad remains colorless must be repeated to ensure complete saturation of the pad with oral fluid. If the second test is equal to the first, the result must be interpreted as negative (absence of alcohol).

(B) Presumptive positive result for alcohol: the alcohol test produces a color change towards green or blue in the presence of an alcohol concentration in the saliva equal to 0.02% BAC or higher. At higher dialcol concentrations, close to 0.30% BAC, the color can become gray-gray.

In Fig. F the oral fluid sample is positive for alcohol

because there have been color changes (from green / blue to dark gray) of the alcohol pad.

Fig F. Example of a positive presumed result of the alcohol test

(2) Drug test results:

(A) Negative result for drugs : in each of the windows of the edema test, colored lines must be observed: one in the two control zones (C) and another next to the specific abbreviation of the drug (eg AM, OP, CO) in the test area (T). See the example in Fig. G.

The color of the test band may be slightly darker or brighter than the control band. Any band that can be visually noticed, no matter how weak, must be interpreted as a negative result. Read each test independently. Don't compare the intensity of different tests.

In Fig. G below, the sample of oral fluid is negative peranfetamine, opiates and cocaine because bands are visible in the zonedel tests related to AM, OP and CO .

Fig G. Example of a negative drug test result

(B) Presumptive positive result for drugs : when the corresponding band is visible in the control region (C) and no band appears in the specific region of the test, the result must be deemed presumptive positive for that particular drug. In Fig. H below, the oral fluid sample is presumptive positive for phencyclidine, methamphetamine and THC because there are no visible bands in the test areas related to AM, OP and CO .

Fig H. Example of a presumptive positive drug test result

(c) Invalid results : when no bands appear in the control area (C), the test should not be considered valid regardless of the result obtained in the test area. If the test is invalid, check the test procedures and samples. Repeat the test using a new device. In Fig. I below, the test is invalid because there are no bands in the control areas .

Fig. I Example of invalid test results

Important: read each test independently. Don't compare the intensity of different bands. If a faded band is obtained in the test area for a specific test, the sample should be considered negative. The OratectPlus device for drug and alcohol screening in the oral fluid provides qualitative results for the presence of drugs or drugs and alcohol at a specific cutoff concentration. For confirmation of a presumptive positive result with regard to drugs of abuse, a more specific quantitative method (GC / MS or LC / MS) should be used.

Collection and management of the sample for the confirmation test
• For devices with any expected positive results, the collection pad must be removed and sent to a laboratory for confirmation testing.
• Insert the transparent cap on the collection pad and detach both. Make sure not to damage or alter the collection pad.
• Place the collection pad in the confirmation vial included in the package.
• Recap the vial and send it to the laboratory for the confirmation test (the sample must be stored at 15-30 ° C and analyzed as soon as possible after collection).
• Follow standard procedures for chain of custody.
• To confirm a presumptive positive alcohol test, use a theatrometer or blood test.

Quality check
The OratectPlus device for the screening of drugs and alcohol in the oral liquid is equipped with integrated control bands positioned in the control zones (C) which serve to indicate that the test was performed correctly. These control bands must always appear, regardless of the presence of drugs. The presence of colored bands in the control zones verifies that,

1. a correct sample volume was used
2. you have managed to get the correct flow.

If the control bands do not appear, the device must be discarded.

Limitations of the procedure
• The test is intended for exclusive use with human oral fluid.
• Positive results only indicate the presumed presence of drugs and / or alcohol. However, it does not indicate or measure a state of intoxication.
• Technical and procedural errors, in addition to certain types of substances present in some products and medicines, can interfere with the test and give rise to false results.

Test performance
Precision - Drug abuse test

For each individual drug test, an artificial oral fluid solution was added to a standard drug in different concentrations (0%, 50%, 200% and 300%). For each concentration, a total of 20 tests were performed to evaluate leprestazioni. The table below summarizes the results obtained with the OratectPlus device for drug and alcohol screening in the oral fluid.

50% 300% + - + 0 0 20 0 0 20 0 1 20 0 0 20 0 0 20 0 0 20 0 0 20 0 1 20
Type of training Total number of tests /
Concentration
Concentration
0% 200%
- - + + -
MYSELF 20 20 20 0 20 0
MDMA 20 20 20 0 20 0
TH 20 20 20 0 19 0
CO 20 20 20 0 20 0
AM 20 20 20 0 20 0
OP 20 20 20 0 20 0
PC 20 20 20 0 20 0
BZO 20 20 20 0 19 0

Precision - Alcohol test
For the alcohol test, saliva was obtained by rinsing with positive control solutions in ethanol at various BACs (0.02%, 0.04% and 0.06%). A negative saliva sample was used to test the 0% concentration. For each concentration, a total of 15 tests were performed to evaluate the performance. The table below summarizes the results obtained with the OratectPlus device for drug and alcohol screening in the oral fluid:

Test BAC 12:04% - + - 15 14 0
Total number of tests /
Concentration
0.00% 12:02% 12:06%
+ - - + +
Alcohol 15 0 1 0 15 15

Specificity
Specificity tests were performed for each drug adding compostestructurally related to an artificial oral fluid solution. The results are expressed as a quantity of compound, in ng / ml, which produced a positive result.

Approximate% of
cross reactivity
2.5% 8.3% 100% 83% 100% 5% 1% 0.5% 5000 4000 80 40% 40 400% 10 10% 110% 100% 0.4% 100% 62.5% 3.2% 200 40 100 100 0.3% 0.3% 50% 83% 100% 100% 17% 67% 17% 14% 100% 25 100 4 10 12 3 30 8 20 6 5 3 10 10 100 15 20 50 15 15 10
Type of training Concentration
approximate (ng / ml)
ME / MDMA
Desipramine 10000 0,25%
d, l-ephedrine 1000 2.5%
1R, 2S l-Ephedrine 1000 2.5%
p-Idrossimetanfetamina 1000
MDEA 300
MDMA 25
d, l-methamphetamine 30
d-Methamphetamine 25
I-Methamphetamine 500
Metossifenamina 2500
Phenylephrine 5000
d-Pseudoephedrine HCl 0.5%
trimethobenzamide 0.6%
TH
cannabinol 50%
Δ-8-Tetrahydrocannabinol 100
Δ-9-Tetrahydrocannabinol 100%
11-nor-Δ-8-THC-9-COOH 10
11-nor-Δ-9-THC-9-COOH 400%
11-Hydroxy-Δ9-THC 400
CO
benzoylecgonine 18
Cocaine 20
ecgonina 5000
AM
d-Amphetamine 25
d, l-amphetamine 40
I-Amphetamine 800
d, Ip-Cloranfetamina 12.5%
MDA 62.5%
MDEA 25%
Phentermine 25%
β-Phenylethylamine 8000
tyramine 8000
OP
6-Acetilcodeina 20
6-acetylmorphine 12
Codeine 10
dihydrocodeine 10
Ethyl morphine 60
Heroin 15
Hydrocodone 60
Hydromorphone 70
Morphine 10
Morphine-3-beta-D-glucuronide 40%
nalorphine 10%
PC
phencyclidine 100%
BZ
Alprazolam 50%
bromazepam 42%
Chlordiazepoxide 167%
clobazam 16.7%
Clonazepam 63%
delorazepam 25%
Diazepam 83%
estazolam 100%
flunitrazepam 167%
flurazepam 50%
Lorazepam 50%
lormetazepam 5%
Nitrazepam 33%
nordiazepam 25%
oxazepam 10%
Prazepam 33%
Temazepam 33%
triazolam 50%

Alcohol test
The alcohol test reacts with methyl, ethyl and allyl alcohols, but does not react with alcohols with more than five carbon atoms such as glycerin, glycerol eserine. This property is the result of the specificity of the enzyme alcohol oxidase extracted from yeast.

Interference
The following compounds were added to an artificial summer fluid solution established that no cross-reactions occur with the OratectPlus device for drug and alcohol screening in the oral fluid at the concentration of 10 µg / ml (10,000 ng / ml):

Acetaminophen
Lithium salt of acetacetic acid
Acetone
6-Acetylcodeine (except OP test)
6-Acetylmorphine (except for OP tests)
Acetylsalicylic acid
Albumin
Allobarbital
Alphenal
Alprazolam (except BZ analysis)
Amitriptyline
amobarbital
amoxapine
Amoxicillin
d-Amphetamine (except AM test)
d, l-Amphetamine (except AM test)
l-Amphetamine (except AM test)
Ampicillin
Apomorphine
Aprobarbital
l-Ascorbic acid
Aspartame
Atropine
barbital
Benzyl acid
benzocaine
Benzoic acid
Hydro benzoylecgonine (except CO test)
Bilirubin
Alprazolam (except BZ analysis)
d-brompheniramine
Buprenorphine Butalbital
Butetal
Caffeine
cannabidiol
Cannabinol (except TH test)
chloral hydrate
Chlordiazepoxide (except BZ analysis)
Chloroanphetamine (DL-p-)
Hydrochloride (except AM test)
Chloroquine
d-Chlorpheniramine
chlorpromazine
Cholesterol
Clobazam (except BZ analysis)
Clomipramina
Clobazam (except BZ analysis)
Cocaine (except CO tests)
Codeine (except OP tests)
Cortisone
l-Cotinine
Creatine
Creatinine
cyclobenzaprine
Delorazepam (except BZ analysis)
Desoxycortisone acetate
Desipramine (except ME tests)
dextromethorphan
Diazepam (except BZ analysis)
Dihydrocodeine (except OP tests)
4-Dimetilaminoantipirina
Diphenhydramine
Dopamine (3-Hydroxytyramine)
Doxepin hydrochloride
doxylamine
Ecgonine (except CO tests)
Ecgonine methyl ester
d, E-Ephedrine (except AM test)
l-Ephedrine
1R, 2S l-Ephedrine (except ME tests)
1S, 2R d-Ephedrine
l-epinephrine
Erythromycin
Estazolam (except BZ analysis)
b-Estradiol
Estrone-3-sulfate potassium salt
Ethanol
Ethyl morphine (except OP tests)
Ethylidin-1,5-dimethyl-1-3,3-diphenylpyrrolidine perchloric salt
Estazolam (except BZ analysis)
Flurazepam (except BZ analysis)
Furosemide
Gentisic acid
Glucose
glutethimide
Guaiacol glyceryl ether
Hemoglobin
Heroin (except OP test)
p-hydroxymethamphetamine (Pholderin) (except ME tests)
Ibuprofen
Imipramine
Hippuric acid
Idroclorotizide
Hydrocodone (except OP tests)
hydrocortisone
Hydromorphone (except OP test)
11-Hydroxy-Δ-9-Tetrahydrocannabinol (except TH test)
d, I-Isoproterenol
l-Isoproterenol HCl
Lidocaine
Lorazepam (except BZ analysis)
Lormetazepam (except BZ analysis)
MDA (except AM test)
MDEA (except AM and ME tests)
MDMA (except ME tests)
meperidine
d, l-methadone
d-Methamphetamine (except ME tests)
d, 1-Methamphetamine (except ME tests)
l-Methamphetamine (except ME tests)
Methoxyphenamine (except ME tests)
2-Methylamine-Propiophenone HCl
methylphenidate
Morphine (except OP tests)
Morphine-3-beta-D-glucuronide (except OP tests)
Nalidixic acid
Nalorphine (except OP tests)
Naloxone
Naltrexone hydrochloride
d-Naproxen
Niacinamide
Nitrazepam (except BZ analysis)
Nordiazepam (except BZ analysis)
Nordoxepin hydrochloride
d, l-Norefedrina hydrochloride
norethindrone
d-norpropoxyphene
Nortriptyline hydrochloride
Oxalic acid
Oxazepam (except BZ analysis)
Oxolinic acid
Oxycodone
papaverine
Penicillin-G (Benzilpenicillin)
pentazocine
Pentobarbital
perphenazine
Phenylcyclidine (except PC test)
pheniramine
Phenobarbital
Phenothiazine
Fentermine (except AM test)
Phenylephrine (except ME tests)
b-Phenylethylamine (except AM test)
d, 1-Phenylpropanolamine hydrochloride
Prazepam (except BZ analysis)
Prednisolone
procaine
promazine
Promethazine
d-Propoxyphene
protriptyline
d-Pseudoephedrine HCl (except ME tests)
quinidine
Ranitidine
Riboflavin
Salicylic acid
secobarbital
Serotonin
Sodium chloride
sulfamethazine
Sulindac
Temazepam (except BZ analysis)
Tetracycline
-8-Tetrahydrocannabinol (except TH test) Δ-9-Tetrahydrocannabinol (trannetest TH)
11-nor-Δ-8-THC-9-COOH (except TH test)
11-nor-Δ-9-THC-9-COOH (except TH test)
Thiamine
thioridazine
Triazolam (except BZ analysis)
trifluoperazine
Trimethobenzamide (except ME tests)
Trimipramine Maleato
tryptamine
d, l-tryptophan
Tiramina (except AM test)
d, l-Tyrosine
Uric acid
Verapamil
zomepirac

Alcohol test
The following substances may interfere with the OratecPlus device for the screening of drugs and alcohol in the oral fluid when using samples other than the fluid:

(1) Agents that promote color development: peroxides and strong oxidants
(2) Agents that inhibit color development:
reducing agents: ascorbic acid, tannic acid, pyrogallol, mercaptans and tosylates, oxalic acid and uric acid.
Bilirubin, L-dopa, L-methyldopa and metampirone.

The substances listed above do not normally appear in the oral fluid in sufficient quantity to interfere with the test. However, special care must be taken to prevent them from being introduced into the mouth during the 15 minutes preceding the test.

Bibliography of suggested readings
1. Wong, R. The Current Status of Drug Testing in the US Workforce, American Clinical Lab, vol. 21 (1), page 21-23, 2002.
2. Caplan, Y. and Goldberger, B., Alternative Specimens for Workplace Drug Testing, J.Analytical Toxicology, vol. 25, p. 396-399, 2001.
3. Schramm, W., Smith, R. and Craig, P., Drugs of Abuse in Saliva: A Review, J.Analytical Toxicology, vol. 16, p. 1-9, 1992.
4. Mandatory Guidelines for Federal Workplace Drug Testing Programs, April 13, 2004 (69FR 19644).
5. Wong, R. On-site Oral Fluid Drug Testing by Oratect, in Drugs of Abuse: Body Fluid Testing, Wong, R and Tse, H ed., Humana Press, p146-158, 2005.
6. Bergmeyer, HU, Grabl, M & Walter, H. in Methods of Enzymatic Analysis, 3rd ed.Vol.II, ed. by Bergmeyer, HU, Verlag Chemie, Weinheim, 1983, P.143.
7. Blanke, RV in Fundamentals of Clinical Chemistry, ed. by Tietz, NW, WB SaundersCo., Philadelphia, 1970, P. 114
8. McCall, KEL, Whiting, B., Moore, MR & Goldberg, A., CLIN. SCI., 56, 283-286,1979.
9. Jones, AW, CLIN.EXP.PHARMACOL.PHYSIOL. 6, 53-59, 1979.
10. Jones, AW, CLIN.CHEM. 25, 1394 - 1398, 1979.

Code HMA11 / HM12

Test 8 drugs Oratect Plus (2024)

References

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